音华生物—优选PCR试剂

JAK/STAT 信号通路基因表达 PCR 芯片可用于研究与 JAK 和 STAT 介导的信号通路有关的 84 个基因的表达。该芯片代表了所有已知的 JAK 和 STAT 家族成员、激活受体、与 STAT 蛋白相关的核内共同因子和共激活因子，以及STAT 诱导基因和信号通路的负调控基因。通过实时定量 PCR 的方法，研究者即能够利用该芯片简单可靠地同时检测 JAK/STAT 信号通路相关的基因表达。

JAK/STAT Signaling: Janus Kinase Activity: JAK1, JAK2, JAK3, TYK2.

STAT Family: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6.

Regulators of the JAK/ STAT Pathway: PIAS1, PIAS2, PRL, PTPN1, PTPRC, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5.

Receptors that Bind and Activate JAK Proteins: CSF1R, EGFR, EPOR, F2R, GHR, IFNAR1, IFNGR1, IL10RA, IL2RA, IL2RG, IL4R, IL6ST, INSR, MPL, PDGFRA, SH2B1.

SH3/SH2 Adaptor Protein Activity: CRK, GRB2, SRC, STAM.

Transcription Factors or Regulators that Interact with STAT Proteins:

Transcriptional Regulation: HMGA1, SMAD3, SPI1.

RNA Polymerase II Transcription Factor Activity: JUNB, SP1, USF1.

Transcriptional Coactivator/Corepressor: JUNB, PIAS1, SMAD1, SMAD5, SP1, YY1.

Other Transcription Factors and Regulators: CEBPB, CRK, GATA3, IRF1, IRF9 (ISGF3G), JUN, MYC, NFKB1, NR3C1 (GRL), SMAD2, SMAD4.

Genes Induced by STAT Proteins: STAT1: CXCL9 (MIG), IRF1, JUNB, NOS2 (iNOS).

STAT3: A2M, BCL2L1 (BCL-X), CCND1, CDKN1A (p21CIP1/WAF1), CEBPD, CRP, FAS (TNFRSF6), IRF1, LRG1, MCL1, MYC, SOCS1, SOCS3.

STAT4: FCGR1A, IFNG, IRF1, MYC. STAT5: BCL2L1 (BCL-X), CCND1, CDKN1A (p21CIP1/WAF1), IL2RA, IRF1, OSM.

STAT6: FCER2, GATA3, IL4, IL4R (CD124).

STAT1/STAT2/p48: ISG15 (G1P2), OAS1.

Apoptosis: AKT1, BCL2L1 (BCL-X), CDKN1A, F2, F2R, FAS (TNFRSF6), IL2RA, MCL1, NFKB1, PRLR, STAT1.

Cell Growth and/or Maintenance: Cell Cycle: CCND1, CDKN1A (p21CIP1/WAF1), EGFR, F2, F2R, IL2RA, IRF1, JAK2, MYC, STAT1.

Cell Growth: A2M, EGFR, GHR, IFNG, IL4, INSR, OSM, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5.

Cell Prolifeion: CSF1R, IL2RG, IL4, MPL, OSM, PDGFRA, SMAD3.

Cell Differentiation: IL20, IL4, NOS2 (iNOS), SOCS2, SOCS5.

Immune Response: Acute-Phase Response: CEBPB, CRP, F2, STAT3.

Humoral Immune Response: FCER2, CSF1R, IL4, NFKB1, YY1.

Inflammatory Response: CEBPB, CRP, CXCL9, IL20, NFKB1, NOS2 (iNOS), NR3C1 (GRL).

Other Genes Involved in the Immune Response: CXCL9 (MIG), FAS (TNFRSF6), FCGR1A, ISG15 (G1P2), IFNG, IL2RA (CD25), IL2RG, IL4R (CD124), IL6ST (GP130), IRF1, IRF9 (ISGF3G), OAS1, OSM, PRLR, PTPN11, STUB1.