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人 Notch 信号通路增强版基因表达 PCR 芯片可以同时检测与 Notch 信号通路相关的 84 个基因表达。该芯片同时包含了 16 个通过实验验证得到的显著标志基因，通过分级运算程序可计算得到活性分值。通过实时定量 PCR 的方法，研究者即能够利用该芯片简单可靠地同时检测 Notch 信号通路相关基因的表达。
Notch Signaling Pathway: Notch Ligands: NOTCH1, NOTCH2, NOTCH3, NOTCH4.
Notch Binding: DLL1, DLL3, DLL4, DTX1, JAG1, JAG2, LFNG, MFNG, NUMB, RFNG.
Notch Receptor Processing: ADAM10, ADAM17 (CD156B), NCSTN, PSEN1, PSEN2, PSENEN (PEN2).
Transcription Factors & Cofactors: EP300, HDAC1, MAML1, MAML2, NCOR2, RBPJL, SNW1 (SKIIP).
Notch Target Genes: Apoptosis: CDKN1A (p21CIP1/WAF1), CFLAR (CASPER), FOSL1 (FRA1), ID1, IL2RA (CD25), NFKB1, PTCRA.
Cell Cycle: CCND1, CDKN1A (p21CIP1/WAF1).
Cell Adhesion: CD44, ERBB2 (HER2).
Cell Differentiation & Development: DTX1, HES1, HES5, HEY1, HEY2, HEYL, JAG1, KRT1, LFNG, LOR, NOTCH1, PPARG.
Neurogenesis: ERBB2 (HER2), FOS, HES1, HEY1.
Immune Response: CHUK (IKKa), IFNG, IL2RA (CD25), NFKB1, NFKB2, STAT6.
Transcription Factors: FOS, FOSL1 (FRA1), HES1, HES5, HEY1, HEY2, HEYL, ID1, NFKB1, NFKB2, PPARG, STAT6.
Other Genes Involved in the Notch Signaling Pathway:
Apoptosis: AXIN1, CTNNB1.
Cell Cycle: AXIN1, CCNE1, FIGF (VEGFD), JAG2, NOTCH2.
Cell Prolifeion: FIGF, LRP5.
Cell Differentiation: PAX5, SHH.
Neurogenesis: PAX5.
Transcription Factors & Cofactors: AES (Groucho), CBL, CTNNB1, GLI1, HOXB4, HR, PAX5, POFUT1, RUNX1 (AML1), TLE1. Other Genes: LMO2, MMP7, SEL1L.
Pathways that Crosstalk with the Notch Signaling Pathway:
Hedgehog Signaling: GLI1, GSK3B, SHH, SMO.
WNT Signaling: AES (Groucho), AXIN1, CTNNB1, FZD7, GSK3B, LRP5, TLE1, WISP1.
Pathway Activity Signature Genes: ADA, AFAP1L2, DTX1, H19, HES4, HES5, HEY2, HEYL, NRARP, SCGB1A1, SERPINA3, SLC6A12, SNAI2, TFF1, TNFSF10, UBD.