- 产品详情
- 产品参数
- 产品评论
TGFß/BMP 信号通路基因表达 PCR 芯片基因表达 PCR 芯片可用于研究 TGFß/BMP 介导的信号转导相关的 84 个基因的表达，同时测定实验组样本中 TGF 信号通路活性是被激活，抑制还是没有变化。该芯片涵盖了 TGFß 超级家族的细胞因子和受体。该芯片同时包含了 16 个通过实验验证得到的显著标志基因，通过分级运算程序可计算得到活性分值。通过实时定量 PCR，使用者通过实时定量 PCR，使用者即能够利用该芯片简单可靠地测定 TGF 信号通路活性并同时检测 TGF /BMP 介导的信号转导相关基因的表达。
TGFβ Superfamily Ligands
Activin: INHA.
BMP: AMH, BMP1, BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, GDF2 (BMP9), GDF3 (VGR-2), GDF5 (CDMP-1), GDF6, GDF7.
Nodal: NODAL.
TGFβ: TGFB1, TGFB2, TGFB3.
Inhibitor/Cofactors: BAMBI, CHRD, DCN, LEFTY1, LTBP1, NOG, TGFBI, THBS1, TGIF1.
TGFβ Superfamily Receptors
Activin: ACVR1 (ALK2), ACVR2A, ACVRL1 (ALK1).
BMP: AMHR2, BMPR1A (ALK3), BMPR1B (ALK6), BMPR2.
TGFβ: TGFBR1, TGFBR2, TGFBR3.
Transcription Factors and Regulators: GSC, ID1, JUNB, MYC, SMAD1 (MADH1), SMAD2 (MADH2), SMAD3 (MADH3), SMAD4 (MADH4), SMAD5 (MADH5), SMAD7, SOX4, STAT1, TGFB1I1.
SMAD Target Genes
TGFβ/Activin-Responsive: ATF4, CDKN1A (p21WAF1/p21CIP1), CDKN1B (p27KIP1), CDKN2B (p15INK2B), COL1A1, COL1A2, DCN, EMP1, GADD45B, GSC, HERPUD1, IFRD1, IGF1, IGFBP3, IL6, JUNB, MYC, PDGFB, SERPINE1 (PAI-1), TGFB1I1, TNFSF10, TGFBI, TGIF1.
BMP-Responsive: BGLAP (Osteocalcin), ID1, ID2, JUNB, SOX4, STAT1.
Molecules Regulating Signaling of the TGFβ Superfamily: BAMBI, BMPER, CDKN2B (p15INK2B), CHRD, ENG (Evi-1), NOG, PLAU (uPA), SMURF1.
Adhesion and Extracellular Molecules
Adhesion Molecules: BGLAP (Osteocalcin), ENG (Evi-1), TGFB1I1, TGFBI.
Extracellular Matrix Structural Constituents: BGLAP (Osteocalcin), COL1A1, COL1A2, LTBP1, TGFBI.
Genes Involving in Cellular and Developmental Processes
Apoptosis: CDKN1A (p21WAF1/p21CIP1), CDKN1B (p27KIP1), IGFBP3, INHA, STAT1, TGFB1.
Embryonic Development: BMP4, SMAD3, SMURF1.
Muscle Development: DCN, IGF1, SMAD3.
Neurogenesis: INHA, NOG.
Reproduction: AMH, AMHR2, INHA.
Skeletal Development: BGLAP (Osteocalcin), BMP1, BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMPR2, CHRD, COL1A1, COL1A2, IGF1, INHA, NOG.
Pathway Activity Signature Genes: ACTC1, BMPR2, EGR2, FAS, FGF2, FSTL3, JUNB, KANK4, KLHL24, NOV, PMEPA1, SERPINE1, SMAD6, SOX4, STK38L, UBASH3B.