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TNF 信号通路基因表达 PCR 芯片可以同时测定 84 个与 TNF 信号通路相关的关键基因。这些关键基因参与了 TNF 配体、受体信号通路，或者是表达受到了 TNF 信号通路的调控。其中包括 TNF 超家族、TNF 受体超家族、以及与 TNFR1 和 TNFR2 信号通路相关的基因。通过实时定量 PCR 的方法，研究者即能够利用该芯片简单可靠地同时检测 TNF 信号通路相关基因的表达。
TNF Superfamily Members: Induction of Apoptosis: FASLG, LTA, TNFSF10, TNFSF14, TNFSF8.
CasPAse Activation: TNFSF15.
CasPAse Inhibition: TNFSF14.
Anti-apoptosis Genes: CD40LG, TNF, TNFSF18.
Other Apoptosis-Related Genes: CD70 (TNFSF7), TNFSF9.
Inflammatory Response: CD40LG, TNF.
NFκB Signaling Pathway: FASLG, TNF, TNFSF10, TNFSF14, TNFSF15.
Other TNF Superfamily Members: LTB, PGLYRP1, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF4, PSMG2.
TNF Receptor Superfamily Members: Induction of Apoptosis: FAS, TNFRSF10A, TNFRSF10A, TNFRSF10B, TNFRSF19, TNFRSF25, CD27 (TNFRSF7), TNFRSF9, TRADD.
CasPAse Activation: TNFRSF10A, TNFRSF10B.
CasPAse Inhibition: CD27 (TNFRSF7).
Anti-apoptosis Genes: FAS, TNFRSF10D, TNFRSF18, TNFRSF6B, CD27 (TNFRSF7).
Other Apoptosis Genes: CD40, LTBR, NGFR, TNFRSF10C, TNFRSF11B, TNFRSF12A, TNFRSF14, TNFRSF1A, TNFRSF1B, TNFRSF21.
Inflammatory Response: CD40, TNFRSF1A.
NFκB Signaling Pathway: CD40, EDA2R, LTBR, TNFRSF10A, TNFRSF10B, TNFRSF1A, CD27 (TNFRSF7), TRADD.
JNK Signaling Pathway: EDA2R, TNFRSF19, CD27 (TNFRSF7).
Other TNF Receptor Superfamily Members: TNFRSF11A, TNFRSF13B, TNFRSF13C, TNFRSF17, RELT, TNFRSF4, TNFRSF8.
TNFR1 Signaling Pathway: Induction of Apoptosis: CASP3, CRADD, FADD, TRADD.
CasPAses: CASP2, CASP3, CASP8.
Anti-apoptosis Genes: BAG4, CASP2, TNF.
Other Apoptosis Genes: DFFA, PAK1, TNFRSF1A, TRAF2.
Inflammatory Response: TNF, TNFRSF1A.
NFκB Signaling Pathway: CASP8, FADD, TNF, TNFRSF1A, TRADD.
JNK Signaling Pathway: MAP2K4, MAPK8, PAK1.
Transcription Regulators: JUN, PARP1, RB1, TNF, TNFRSF1A.
TNFR1 Signaling Pathway: ARHGDIB, CAD, HRB, LMNA, LMNB1, LMNB2, MADD, MAP3K1, MAP3K7, PAK2, PRKDC, SPTAN1.
TNFR2 Signaling Pathway: Induction of Apoptosis: IKBKG, LTA, TRAF3.
Anti-apoptosis Genes: NFKB1, TNFAIP3.
Other Apoptosis Genes: NFKBIA, TNFRSF1B, TRAF1, TRAF2.
Inflammatory Response: NFKB1.
NFκB Signaling Pathway: CHUK, IKBKB, IKBKG, NFKBIA, TNFAIP3.
Transcription Regulators: IKBKB, IKBKG, NFKB1, NFKBIA.
TNFR2 Signaling Pathway: DUSP1, AGFG1, IKBKAP, MAP3K1.