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WNT 信号通路基因表达 PCR 芯片可用于研究与 WNT 介导的信号转导相关的 84 个基因的表达，同时测定实验组样本中经典的 WNT/β-catenin 信号通路活性是被激活，抑制还是没有变化。该芯片同时包含了 16 个通过实验验证得到的显著标志基因，通过分级运算程序可计算得到活性分值。每块芯片上都设定了一组对照通过ΔΔCT 方法分别对反转效率，基因组 DNA 含量和 PCR 效率进行评估。使用该芯片研究者即能够利用该芯片简单可靠地测定经典 WNT/β-catenin 信号通路活性并同时检测 WNT 介导的信号转导相关基因的表达。
WNT Signaling Pathways:
Canonical: APC, AXIN1, AXIN2, CSNK1A1, CTBP1, CTNNB1, CTNNBIP1 (ICAT), DKK1, DKK3, DVL1, DVL2, EP300, F1, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, LEF1, LRP5, LRP6, NKD1, PORCN, RUVBL1, SFRP1, SFRP4, SKP2, SOX17, TCF7, TCF7L1, WIF1, WNT1, WNT10A, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT6, WNT7A, WNT7B, WNT8A.
Planar Cell Polarity (PCP): DAAM1, DVL1, DVL2, MAPK8 (JNK1), NKD1, PRICKLE1, RHOA, VANGL2, WNT9A.
WNT/Ca+2: FZD2, NFATC1, WNT1, WNT10A, WNT11, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT9A.
WNT Signaling Negative Regulation: APC, AXIN1, AXIN2, BTRC (bTrCP), CCND1, CTBP1, CTNNBIP1 (ICAT), DKK1, DKK3, FBXW11, FRZB (FRP-3), KREMEN1, LRP6, NLK, NKD1, SFRP1, SFRP4, SOX17, WIF1.
WNT Signaling Target Genes: AXIN2, BTRC (bTrCP), CCND1, CCND2, DAB2, FOSL1 (FRA-1), JUN, MMP7, MYC, PITX2, PPARD, WISP1.
Developmental Processes: Cell Fate: CTNNB1, DKK1, WNT1, WNT3, WNT3A.
Tissue Polarity: AXIN2, FZD2, FZD3, FZD5, FZD6, VANGL2.
Cell Growth & Prolifeion: APC, CCND1, CCND2, CTBP1, CTNNB1, CTNNBIP1 (ICAT), DAB2, EP300, FGF4, FOSL1, FZD3, JUN, LRP5, MMP7, MYC, PPARD, WISP1, WNT3A.
Cell Migion: APC, DKK1, LRP5, LRP6, RHOA, WNT1.
Cell Cycle: APC, BTRC (bTrCP), CCND1, CCND2, CTNNB1, EP300, FOSL1, JUN, MYC, RHOA, RUVBL1, TCF7L1.
Cellular Homeostasis: APC, FZD2, JUN, MYC.
Pathway Activity Signature Genes: BOD1, CALM1, CCND1, CCND2, CHSY1, CXADR, CYP4V2, HSPA12A, LEF1, MT1A, MTFP1, MTSS1, MYC, NAV2, PRMT6, SKP2.