音华生物—优选PCR试剂

GPCR 信号通路发现者基因表达 PCR 芯片包含 84 个与 GPCR 调控的信号转导通路相关基因的表达。芯片中包括的 GPCRs 包括：生物活性的脂受体、代谢型谷氨酸受体（mGluRs）、伽马氨基丁酸 B 型受体、视紫红质样受体和分泌素样受体。芯片也包含了 GPCR 介导的信号通路相关的细胞内信号转导通路的复杂网络成员，具体包括： cAMP/PKA 信号通路、Calcium/PKC 信号通路、Calcium/NFAT 信号通路、PLC 信号通路、酪氨酸蛋白激酶信号通路、PKC/MEK 信号通路、p43/p44MAP 信号通路、p38MAP 信号通路、PI-3 Kinase 信号通路、NO-cGMP 信号通路、 Rho 信号通路、NFkB 信号通路和 Jak/Stat 信号通路。使用该芯片试剂盒及配套试剂检测 RNA 实验标本，研究者可以简单准确的检测和分析 GPCR 调控的信号转导通路相关的基因表达。

G-Protein-Coupled Receptors (GPCRs) Bioactive Lipid Receptors: S1PR1, LPAR1, S1PR3, LPAR2, S1PR2.

Metabotropic Glutamate, GABA- B-like Receptors: CASR, GRM1, GRM2, GRM4, GRM5, GRM7.

Rhodopsin-like Receptors: ADORA2A, ADRB1, ADRB2, AGTR1, AGTR2, AGTRAP, DRD1, DRD2, S1PR1, LPAR1, S1PR3, LPAR2, S1PR2, GALR2, LHCGR, OPRD1, OPRK1, PTGDR, RHO, TSHR.

Secretin-like Receptors: ADORA2A, BAI1, CALCR, CALCRL, CRHR1, CRHR2, GCGR, PTH1R, SCTR.

Other G-protein Coupled Receptors: EDN1.

Pathways Related to G-Protein-Coupled Receptor Protein Signaling DoPAmine Receptor Pathway: DRD1, DRD2, OPRD1.

G-protein Signaling, Coupled to cAMP Nucleotide Second Messenger (cAMP / PKA):ADCY5, ADORA2A, ADRB1, ADRB2, CALCR, CALCRL, CCL2, COL1A1, CRHR1, CRHR2, CYP19A1, DRD1, S1PR1, S1PR3, EDN1, GALR2, GCGR, GNAQ, GNAS, GRM2, GRM4, IL1R1, IL1R2, LHCGR, NOS2, OPRD1, OPRK1, PTGS2, PTH1R, RGS2, TSHR, UCP1, VEGFA.

G-protein Signaling, Coupled to IP3 Second Messenger (PLC): AGTR1, CALCR, CASR, LPAR1, LPAR2, EDN1, GNAQ, GRM5, PIK3CG.

Metabotropic Glutamate Receptor Pathway: GRM1, GRM2, GRM4, GRM5, GRM7.

Neuropeptide Signaling Pathway: BAI1, OPRD1.

Adenosine Receptor Signaling Pathway: ADCY5, ADORA2A.

Calcium Signaing Pathway (PKC, NFAT, etc.): CCL2, CCL4, COL1A1, EGR1, ELK1, ELK4, PTGS2.

PKC Pathway (Ca2+, MEK, etc.): AGTR2, COL1A1, DUSP14, EGR1, FGF2, FOS, IL1R1, IL1R2, JUN, JUNB, MMP9, MYC, NOS2, PRKCA, PTGS2, RGS2, SERPINE1, SOCS1.

Protein Tyrosine Kinase Pathway: ADRB2, AKT1, CCL4, CTGF, PDPK1, PRKCA, RGS2, SOCS1, YWHAZ.

Protein Serine / Threonine Kinase Pathway: AKT1, CDKN1B, PDPK1, PTGDR.

MAPKKK Cascade: ADRB2, AGT, S1PR2, FGF2, GRM1, GRM4, PRKCA, TNF, UCP1.

PI-3 Kinase Pathway: AKT1, BCL2, BCL2L1, CCND1, CDKN1B, CFLAR, PDPK1, PIK3CG, PTGS2.

NO-cGMP Pathway: AGTR2, NOS2, PTGS2, TNF.

Rho Pathway: CDKN1B, CTGF, FOS, IL1B, PTGS2, RHO, SERPINE1.

IκB Kinase / NFκB Cascade: AGT, CFLAR, LPAR1, ICAM1, IL1B, IL2, MAX, NOS2, PTGS2, TNF, VCAM1. JAK-STAT

Cascade: CCL2, CDKN1A, SOCS1.

Other Genes Related to G-Protein-Coupled Receptor Protein Signaling: ARRB1, ARRB2, CCNE1, CCNE2.