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HIV 宿主应答基因表达 PCR 芯片可用于研究参与 HIV 感染宿主应答的 84 个基因的表达。芯片包含与 HIV 感染相关的先天性和获得性免疫基因，以及 HIV 病毒复制关键细胞因子基因。这些基因参与 HIV 病毒加工如结合、融合、脱壳、反转录、入核、整合、转录、RNA 出核、装配和出芽。这一芯片还包含了在 HIV 感染宿主应答中参与 HIV 先天反应的关键基因和参与 HIV 免疫逃避的宿主基因。利用该芯片研究者即能够利用该芯片简单可靠地同时检测 HIV 感染和宿主应答相关基因的表达。
HIV Receptors & Natural Ligands: CCL2 (MCP-1), CCL4(MIP-1B), CCL5 (RANTES), CCR5, CD4, CXCL12 (SDF1), CXCR4.
Cellular Cofactors Involved in HIV Infection: Viral Genome Replication: APOBEC3G, CD209, HTATSF1.
Inflammatory Response: CCR2, CCR3, CCR4.
Antimicrobial Humoral Response: CCR2, YY1.
Apoptosis: EP300, LTBR, PTK2B.
Cell Cycle: CCNT1, CDK7, CDK9, EP300, RBL2, SMARCB1.
Cell Prolifeion: CDK7, CDK9, PTK2B.
Cell Adhesion: CCR3, CD209, PTK2B.
Transcription Factors & Regulators: APEX1, BCL11B, CCNT1, CREBBP, EP300, HMGA1, HTATSF1, NFATC1, RBL2, SMARCB1, TFCP2, TSG101, YY1.
Other Genes: BANF1, BTRC, CBX5, CD247 (CD3Z), COPS6, ELANE, LTBR, PPIA, TRIM5, VPS4A, XPO1.
Innate Immune Response: Humoral Response: IL12B, IL1B, KLRD1, XCL1.
Response to Virus: CCL4 (MIP-1B), CCL5 (RANTES), CCL8 (MCP-2), CXCL12 (CSF1), IFNB1, TNF.
Inflammatory Response: CCL2 (MCP-1), CCL3 (MIP-1A), CCL4 (MIP-1B), CCL5 (RANTES), CCL8 (MCP-2), CXCL12 (SDF1), IL10, IL1B, IL8, SERPINA1, TNF.
Natural Killer Cell Activation: IFNB1, IL12B, IL2.
Defense Response Against PAthogens: CD69, CX3CL1, IFNA1, IFNB1, IFNG.
Cell Adhesion: CCL2 (MCP-1), CCL4 (MIP-1B), CCL5 (RANTES), CD44, CX3CL1, CXCL12 (CSF1), IL8, SELL (LECAM1), TNF.
Other Genes: CD74, CR2, IFNG, IL16, MBL2, PRDX1, SERPINC1 (ATIII), SLPI, TGFB1, TNFRSF1B.
Immune Evasion: CD4, FCAR, MAP3K5.
Cellular Proteins Induced or Activated by HIV Infection: Apoptosis: BAD, BAX, BCL2, CASP3, CASP8 (FLICE), CDKN1A (p21CIP1/WAF1), GADD45A, NFKBIA (IkBa/MAD3), STAT1, TNFSF10 (TRAIL).
Cell Cycle: BAX, BCL2, CDK9, CDKN1A (p21CIP1/WAF1), GADD45A, IRF1, STAT1.
Cell Prolifeion: BCL2, CDK9, CDKN1A (p21CIP1/WAF1), IRF2.
Transcription Factors & Regulators: CDK9, CEBPB, FOS, IRF1, IRF2, NFATC1, NFKBIA (IkBa/MAD3), STAT1, STAT3.