MYC 靶向基因表达 PCR 芯片可用于研究由主要致癌转录因子控制的关键癌症相关的 84 个关键基因的表达。该芯片包含了 MYC 靶向调节诸如凋亡、细胞周期、细胞生长、增殖和分化、DNA 修复、表观遗传学、代谢、蛋白质合成、降解和周转、RNA 处理和信号转导等基本过程的基因。也包含了 MYC、MAX 和其他相关转录因子。利用该芯片,研究者可以方便并且可信地对与 MYC 调控相关的基因进行同时检测。
MYC & Co-Transcription Factors:E2F1, MAX, MAZ, MYCL, MYCN, PIAS2.
Up-Regulated by MYC:AIMP2, APEX1, ATF4, BAX, BCAT1, CAD, CBX3, CCNB1, CCND2, CCT5, CDC25A, CDK4, CHEK1, CKS2, CSTB, CTSC, DDX10, DKC1, E2F1, EIF4A1, EIF4B, EIF4E, ENO1, EXOSC8, FASN, GNL3, HK2, HNRNPA1, HNRNPA2B1, L TA4H, MAT2A, MGST1, MSH2, MTHFD1, NAP1L1, NBN, NCL, NME1(NM23), NOLC1, NPM1, ODC1, PA2G4, PAICS, PCNA, PHB, PO LD2, PPAT, PSMG1, PTEN, PYCR1, RPL13, RPL19, RPL23, RPL27A, RPL5, RPS5, SHMT1, SNRPB, SRM, SRSF1, TERT, TOP1, TP53(p53), TPI1, TYMS, UBE2C, YBX3.
Down-Regulated by MYC:CDKN1B (P27KIP1), CDKN2B (p15INK4b), CSDE1, ID3, ILK, ITGB1, MYC, PTPA, ZFP36L1.
Apoptosis:BAX, CCNB1, GNL3, NPM1, TP53 (p53).
Cell Cycle:CCNB1, CCND2, CDC25A, CDK4, CDKN1B(P27KIP1), CDKN2B(p15INK4b), GNL3, PA2G4, PCNA, TP53(p53).
Cell Growth & Proliferation:CDKN1B (P27KIP1), CKS2, NPM1, PA2G4, PCNA, PHB.
Chromatin Modifying & Associated Proteins:CBX3, NAP1L1.
DNA Repair:AIMP2, APEX1, CHEK1, MSH2, NBN, NPM1, PCNA, TERT, TP53 (p53).
DNA Replication:PCNA, POLD2, TOP1.
Extracellular Matrix (ECM) & Cell Adhesion Molecules:ILK, ITGB1.
Metabolism:BCAT1, CAD, ENO1, FASN, GCLC, HK2, LTA4H, MAT2A, MGST1, MTHFD1, NME1(NM23), ODC1, PAICS, PDK1, PPAT, PYCR1, SHMT1, SRM, TPI1, TYMS.
Protein Synthesis, Degradation & Turnover:CCT5, CSTB, CTSC, EIF4A1, EIF4B, EIF4E, NCL, NPM1, PSMG1, PYCR1, RPL13, RPL19, RPL23, RPL27A, RPL5, RPS5, UBE2C.
RNA Processing & Binding Factors:CSDE1, DDX10, DDX39B, DKC1, EXOSC8, HNRNPA1, HNRNPA2B1, NOLC 1, SNRPB, SRSF1.
Signal Transduction:ILK, NPM1, PDK1, PTEN, PTPA.
Transcription Factors & Cofactors:ATF4, ID3, MYC, TP53 (p53), YBX3, ZFP36L1.
Tumor Suppressor Genes:MSH2, PHB, TP53 (p53).