PPAR 靶基因基因表达 PCR 芯片可以同时检测参与过氧化物酶增殖物激活受体(PPAR)活化和响应的 84 个关键基因的表达。该芯片包括参与脂肪细胞分化,脂质转运和代谢,胰岛素信号的 PPAR 靶基因。同时,参与 PPAR 配体转运以及相关转录因子和辅因子基因也包括在内。利用该芯片,研究者可以方便并且可信地对 PPAR 的信号转导相关基因进行同时检测。
PPARα Targets: Adipogenesis: ADIPOQ, LPL, NR1H3, UCP1.
Fatty Acid Metabolism: ACADL, ACADM, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, CPT1A, CPT1B, CPT2, CYP27A1, CYP4A11, CYP7A1, EHHADH, FADS2, HMGCS2, PLTP, SCD.
Lipid Transport: ADIPOQ, ANGPTL4, APOA1, APOA5, APOC3, LPL, NR1H3, OLR1.
Insulin Signaling: CPT1A, SORBS1.
PPARβ/δ Targets: Adipogenesis: ADIPOQ, ECH1, FABP4, LPL, UCP1.
Fatty Acid Metabolism: ACAA2, ACADL, ACADM, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, CPT1A, CPT1B, CPT2, CYP4A11, CYP27A1, CYP7A1, EHHADH, ETFDH, FABP1, FABP3, FABP4, FADS2, GK, HMGCS2, MLYCD, PLTP, SCD, SLC27A1, SLC27A4.
Lipid Transport: ADIPOQ, ANGPTL4, LPL, OLR1.
Cell Prolifeion: HIF1A, ILK, KLF10, PTEN, PYY.
Insulin Signaling: CPT1A, PDPK1, SORBS1.
Others: PDPK1.
PPARγ Targets: Adipogenesis: ADIPOQ, LPL, NR1H3, UCP1.
Fatty Acid Metabolism: ACADL, ACADM, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, CPT1A, CPT1B, CPT2, CYP27A1, CYP4A11, CYP7A1, EHHADH, FADS2, GK, SCD.
Lipid Transport: ADIPOQ, ANGPTL4, APOE, DGAT1, LPL, NR1H3, OLR1.
Cell Prolifeion: CLU, ELN, HSPD1, TXNIP.
Insulin Signaling: CPT1A, DGAT1, PCK1, SORBS1.
Others: MMP9, PCK1.
PPAR Cofactors: CHD9, CREB1, CREBBP, EP300, FGR, LPIN1, MED1, NCOA3, NCOA6, PPARGC1A (PGC-1a), PPARGC1B (PGC-1ß), PPRC1, PRIC285, SIRT1, SMARCD3, SRC, TGS1.
PPAR Ligand Transport: CD36, FABP1, FABP2, FABP3, FABP4, FABP5, FABP6, FABP7, SLC22A5, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6.
PPAR Transcription Factors: PPARA, PPARD, PPARG, RXRA, RXRB, RXRG.