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TGFß 信号靶标基因表达 PCR 芯片可用于研究 84 个 TGFß 信号转导应答关键基因的表达。该芯片则涵盖了 TGFß 转录因子和多种实验验证得到的高度相关性靶标基因，芯片结果可用来分析 TGFß 信号传导的激活或抑制。通过实时定量 PCR，研究者可以简单可靠地同时分析参与 TGFß 关联细胞活动的基因表达。
Differentiation & Development
Regulation: AGT, BDNF, CTNNB1, EPHB2, HES1, KLF10, NFKBIA (IkBa/MAD3), PPARA, PTHLH, PTK2, RARA, RHOA, RUNX1 (AML1), SHH, TGFB2, TGFBR2.
Other Genes: BRD2, CEBPB, CREB1, DNAJA1, EMP1, ENG (EVI-1), FN1, IFRD1, MAPK14 (p38 MAPK), MMP2 (Gelatinase A), MYOD1, SNAI1.
Prolifeion & Migion
Regulation: ACVRL1 (ALK1), AGT, ATF3, BCL2L1 (BCL-X), BDNF, CDC6, CDKN1B (p27KIP1), CTNNB1, FURIN, HES1, HMOX1, IL10, KLF10, MSX2, MYC, NFKBIA (IkBa/MAD3), PDGFA, PLG, PTGS2 (COX-2), PTHLH, PTK2B, SERPINE1 (PAI-1), SHH, SOX4, TGFB2, TGFBR2, THBS1, TXNIP, VEGFA.
Other Genes: ACTA2(a-SMA), ACVR1 (ALK2), AR, EMP1, FN1, FURIN, IL10, PTK2.
Apoptosis: ACVR1 (ALK2), AGT, AIPL1, CDKN1B (p27KIP1), CREB1, CTNNB1, FURIN, GADD45B, HERPUD1, KLF10, MAP3K7 (TAK1), MAPK8 (JNK1), MSX2, PLG, PTGS2 (COX-2), RAD21, RHOA, RHOB, RYBP, S100A8, SHH, SOX4, TGFB2, TNFSF10 (TRAIL), TXNIP.
Anti-Apoptosis: BCL2L1 (BCL-X), BDNF, CEBPB, CRYAB, HMOX1, IL10, NFKBIA (IkBa/MAD3), PTK2B, THBS1, VEGFA.
Cell Cycle:
Regulation: ACVR1 (ALK2), RAD21.
Other Genes: CDC6, CDKN1B (p27KIP1), GADD45B, PTGS2 (COX-2), RHOB, TGFB2.
Signal Transduction
TGFß Pathway: ACVR1 (ALK2), ACVRL1 (ALK1), CREBBP (CBP), E2F4, ENG (EVI-1), EP300, ID1, ID2, ID3, MSX2, RBL1, SMAD1, SMAD3, SMAD5, SMAD6, SP1, TGFB2, TGFBR2, THBS1.
NF?B Pathway: HMOX1, IL10, MAP3K7 (TAK1), NFKBIA (IkBa/MAD3), RHOA, TNFSF10 (TRAIL). Notch Pathway: HES1, HEY1, NOTCH1.
Hedgehog Pathway: GLI2, SHH.
Wnt Pathway: CTNNB1.
Transcription Factors: TGFß Signaling: CREBBP (CBP), E2F4, EP300, ID1, ID2, ID3, RBL1, SMAD1, SMAD3, SMAD5, SMAD6, SP1.
Others: AR, ATF3, ATF4, BACH1, BHLHE40, CEBPB, CREB1, CTNNB1, FOS, GTF2I, HEY1, KLF10, MBD1, MSX2, MYC, MYOD1, NFIB, PPARA, RARA, RUNX1 (AML1), SOX4, SREBF2.