癌症药物靶标基因表达 PCR 芯片可用于研究抗癌疗法和药物开发相关的 84 个靶标基因的表达。该芯片包含了在癌症发生中失调的基因,参与关键细胞生长途径的基因,如细胞凋亡、DNA 损伤修复、表观遗传学、生长因子和其他信号通路的基因。通过实时定量 PCR 的方法,研究者即能够利用该芯片简单可靠地同时检测肿瘤生成相关基因的表达。
Apoptosis:
BCL2, BIRC5. PI-3 Kinases & Phosphatases: MTOR, PIK3C2A, PIK3C3, PIK3CA.
Growth Factors & Receptors: EGFR, ERBB2, ERBB3, ERBB4, FIGF, FLT1, FLT4, IGF1, IGF1R, IGF2, KDR, KIT, PDGFRA, PDGFRB.
Drug Metabolism: ABCC1, GSTP1, PTGS2, TXN, TXNRD1.
G Protein Signaling: RHOA, RHOB.
Hormone Receptors: ESR1, ESR2, PGR.
Heat Shock Proteins: HSP90AA1, HSP90B1.
Receptor Tyrosine Kinase Signaling: AKT1, AKT2, GRB2.
Cathepsins: CTSB, CTSD, CTSL1, CTSS. Cell Cycle: CDK1, CDC25A, CDK2, CDK4, CDK5, CDK7, CDK8, CDK9, MDM2, MDM4, TERT.
Topoisomerases, Type II: TOP2A, TOP2B.
Transcription Factors: ATF2, HIF1A, IRF5, NFKB1, TP53.
Protein Kinases: AURKA, AURKB, AURKC, PLK1, PLK2, PLK3, PLK4, PRKCA, PRKCB, PRKCD, PRKCE.
RAS Signaling: HRAS, KRAS, NRAS.
Histone Deacetylases: HDAC1, HDAC11, HDAC2, HDAC3, HDAC4, HDAC6, HDAC7, HDAC8.
Poly ADP-Ribose Polymerases: PARP1, PARP2, PARP4, TNKS.
Structural Protein: NTN3.