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亨廷顿氏病基因表达 PCR 芯片可检测直接或间接与亨廷顿氏病（HD）相关的 84 个关键基因的表达。HD，是由于亨廷顿（HTT）基因的 CAG 重复片段扩增所造成的一种常染色体显性遗传性疾病，患者表现为进行性神经功能障碍，并最终导致死亡。利用该芯片研究者即能够利用该芯片简单可靠地同时检测廷顿氏病相关的基因表达。
Huntingtin Cofactors: CLTC, CREBBP, DCTN1, DLG4 (PSD95), EGFR, GRB2, HAP1, HDAC2, HIP1, MAP3K10, NCOR1, PACSIN1, PRPF40A (FNBP3), PTPN11, RCOR1, REST, SIN3A, SP1, SYMPK, TBP, TP53.
Transcription Factor Targets: SP1: AKT1, APOE, AQP1, ARFIP2, BDNF, C3, CASP8 (FLICE), CD44, CLTC, CREBBP, DLG4 (PSD95), FGF12, GJA1, GJB6, GPX1, GRB2, GRIN2A, HAP1, HDAC1, HOMER1, HPCA, HTT, KCNC3, LPL, MAP3K10, PACSIN1, PRKCB, RAB6A, REST, RILP, RXRB, SGK1, SIN3A, SOD1, SOX2, SP1, SYMPK, SYN1, TGM2, TOLLIP, TP53, TUBB.
REST: BDNF, CALB1, DLG4 (PSD95), EEF1A2, ELMO1, FGF12, GABRD, GRIN2A, KCNAB2, KCNC3, NEFL, RPH3A, RXRB, SNAP25, SYN1, TOLLIP, TUBB.
Cytoskeleton: AKT1, CASP8 (FLICE), DCTN1, DLG4 (PSD95), ELMO1, GRIN2A, HAP1, HIP1, HOMER1, IFT57, ITPR1, NCOR1, NEFL, SYMPK, TUBB.
Cytoskeleton Organization: APOE, ARFIP2, ELMO1, NCOR1, NEFL, PACSIN1, TAC1, TUBB.
Ion Transport: AKT1, AQP1, ATP2B2, GABRD, GRIN2A, HOMER1, HTT, ITPR1, KCNAB1, KCNAB2, KCNC3, PPP3CA, SGK1.
Regulation of Synaptic Transmission: APOE, BDNF, CALB1, EGFR, GNAQ, GRIN2A, GRIN2B, HTT, PPP3CA, TAC1.
Postsynaptic Density (PSD): DLG4 (PSD95), GRIN2A, HOMER1, ITPR1.
Synapse: DLG4 (PSD95), GABRD, GRIN2A, GRIN2B, HOMER1, ITPR1, RPH3A, SNAP25, SYN1.
Neurotransmitter Receptors: CNR1, GABRD, GRIN2A, GRIN2B, GRM5, NTRK2.
Dysregulated Processes: Apoptosis: AKT1, APOE, BAX, BDNF, CASP3, CASP8 (FLICE), CD44, CREB1, EEF1A2, EGFR, ELMO1, GJB6, GRIN2A, HIP1, HTT, IFT57, IGF1, MAP3K10, NEFL, NGEF, SGK1, SLC25A4, SOX2, TBP, TP53, TUBB, ZBTB16.
Endocytosis: C3, CLTC, HIP1, PACSIN1.
Oxidation / Reduction: APOE, BBOX1, EGFR, GPX1, KCNAB1, KCNAB2, PLOD2, PPARGC1A, SOD1.
Calcium Signaling/ Homeostasis: APOE, ATP2B2, GNAQ, GRIN2A, GRIN2B, HOMER1, ITPR1, PLCB1, PPP3CA, TAC1, TGM2.
Others: PGK1, RGS4, SLC14A1.