一氧化氮(NO)信号通路 RT2 ProfilerTM PCR Array 包含了表达受第二信使 NO 控制及参与 NO 信号通路的 84 个基因。芯片包括参与 NO 生物合成、过氧化物代谢的基因和参与氧化应激反应的基因。还包括被 NO 诱导或抑制的基因,这些基因能够作为细胞体系中 NO 信号通路激活的指标。利用该芯片研究者即能够利用该芯片简单可靠地同时检测 NO 信号通路相关基因的表达。
Nitric Oxide Biosynthesis: Oxidoreductases: NOS1 (nNOS), NOS2 (iNOS), NOS3 (eNOS), NQO1.
Nitric Oxide Biosynthesis Regulation: DYNLL1, GLA, HSP90AB1 (HSPCB), IL10, INS, NOS1AP.
Other Genes: AKT1, ARG2, DDAH2, DYNLL1, EGFR, GCH1, GCHFR.
Genes Induced by Nitric Oxide: CDKN1A (p21CIP1/WAF1), IL8, JUN, VEGFA.
Genes Suppressed by Nitric Oxide: CCNA1, MYB, TROAP.
Nitric Oxide Signaling Pathway: CAMK1, DLG4 (PSD95), GRIN2D, NOS1 (nNOS), PPP3CA, PRKAR1B, PRKCA.
Superoxide Metabolism: Superoxide Release: ALOX12, DUOX1, DUOX2, NOX5, PRG3.
Oxidoreductases: ALOX12, DUOX1, DUOX2, NOS2, NOX5, SOD1, SOD2, SOD3.
Peroxidases: DUOX1, DUOX2. Other Genes: CCS, NCF1, NCF2, PREX1.
Response to Oxidative Stress: Anti- Apoptosis: MPO, MTL5, NME5, PRDX2, RNF7.
Antioxidants: APOE, MT3, SELS, SOD1, SOD3, SRXN1.
Glutathione Peroxidases: GPX1, GPX2, GPX3, GPX4, GPX5, GPX6.
Oxidoreductases: CAT, EPX, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, LPO, MPO, MSRA, PRDX2, PRDX6, SOD1, SOD2, SRXN1, TPO, TXNRD2.
Peroxidases: CSDE1, CYGB, EPX, GPR156, LPO, MPO, PRDX2, PRDX5, PRDX6 (AOP2), TPO, TTN.
Transcription Regulators: CSDE1, FOXM1, GLRX2, SCRT2, SIRT2, SOD2.
Other Genes: ATOX1, DUSP1 (PTPN16), GSS, KRT1, MBL2, NUDT1, OXR1, PNKP, PRNP, SCARA3, SEPP1, SGK2.